Kersten D, Göber B
Pharmazie. 1984 Aug;39(8):541-6.
Non-isothermal short-term tests to examine the stability of drug solutions, are critically discussed with regard to their application to simple and complex reaction mechanisms. The influence of additional temperature dependences (ionic product of water, activity coefficient) is assayed. By example of the decomposition of tetracaine hydrochloride and acetylsalicylic acid, the evaluation of experimental results is discussed considering these factors.
针对非等温短期试验在简单和复杂反应机制中的应用，对其用于检验药物溶液稳定性的情况进行了批判性讨论。分析了额外温度依赖性（水的离子积、活度系数）的影响。以盐酸丁卡因和乙酰水杨酸的分解为例，在考虑这些因素的情况下讨论了实验结果的评估。
