Smid-Korbar J, Kristl J, Srcic S
Pharmazie. 1984 Sep;39(9):606-8.
In vitro drug liberation results from PMMA (Eudispert)-salt hydrogels are explained from the aspect of polymer concentration, polymer molecular mass, viscosity as well of neutralisation grade and cation (Na+, K+, NH+4, ethanolamine, triethanolamine) of the polymer molecule and solubility properties of the drugs. Drug diffusion through hydrogel is regulated with the polymer network, in dependence of polymer nature and further with die mobility of water. The considered influences predominantly cover each other.
聚甲基丙烯酸甲酯（优得芬）-盐类水凝胶的体外药物释放结果可从聚合物浓度、聚合物分子量、粘度以及聚合物分子的中和度和阳离子（Na+、K+、NH4+、乙醇胺、三乙醇胺）和药物的溶解性等方面进行解释。药物通过水凝胶的扩散受聚合物网络的调节，这取决于聚合物的性质以及水的流动性。所考虑的这些影响因素之间存在着相互覆盖的关系。
