Lücke-Huhle C, Hieber L, Beck-Bornholdt H P
Radiat Res. 1984 Dec;100(3):576-84.
Survival and G2 delay of L929 mouse fibroblasts exposed to 3.4-MeV alpha particles depend on the cell age at the time of irradiation. Greatest sensitivity for both endpoints has been found at the G1/S transition: The surviving fraction of G1/S cells is reduced to 0.11 following 1 Gy of alpha particles compared to 0.31 for early G1 cells. The G2 + M transit time rises from 3 hr for control cells to 22 and 30 hr for cells irradiated with 0.3 Gy in G2 or at the G1/S boundary, respectively. Cells irradiated in early G1 do not show increased G2 + M transit times. Growth delay as calculated for the entire population increases linearly with dose by 23 hr/Gy of alpha particles.
暴露于3.4兆电子伏特α粒子的L929小鼠成纤维细胞的存活和G2期延迟取决于照射时的细胞年龄。在G1/S期转换时发现这两个终点的敏感性最高：与早期G1期细胞的0.31相比，1 Gyα粒子照射后G1/S期细胞的存活分数降至0.11。G2+M期的转运时间从对照细胞的3小时分别增加到在G2期或G1/S边界用0.3 Gy照射的细胞的22小时和30小时。在早期G1期照射的细胞未显示G2+M期转运时间增加。整个群体计算的生长延迟随α粒子剂量以23小时/戈瑞线性增加。
