Lundell G, Blomgren H, Cedermark B, Silfverswärd C, Theve T, Ohman U
Radiother Oncol. 1984 Mar;1(4):325-32. doi: 10.1016/s0167-8140(84)80020-1.
Eighteen patients with advanced and inoperable colorectal adenocarcinomas were treated with high doses of alpha 2 Interferon (Schering-Plough Corporation). The patients were randomized to receive either subcutaneous injections of 20 X 10(6) I.U./m2 three times weekly for 3 months, or pulsed treatments of 50 X 10(6) I.U./m2 daily, given intravenously, for 5 consecutive days every 4 weeks. No objective tumour regression was seen in any patient. The side effects were considerable.
18例晚期不可切除的结肠腺癌患者接受了大剂量的α2干扰素（先灵葆雅公司生产）治疗。患者被随机分为两组，一组每周皮下注射20×10⁶国际单位/平方米，共3个月，每周3次；另一组每4周静脉注射50×10⁶国际单位/平方米，连续5天，进行脉冲治疗。所有患者均未出现客观的肿瘤消退。副作用较为严重。
