Abbatucci J S, Boulier N, de Ranieri J, Mandard A M, Tanguy A, Busson A
Radiother Oncol. 1984 Aug;2(2):115-21. doi: 10.1016/s0167-8140(84)80047-x.
A considerable improvement in the prognosis of soft tissue sarcomas in the adult has been obtained with a treatment schedule combining surgery and routine radiation therapy (possibly preoperative and certainly postoperative); local recurrences, the predominant element in the natural history of the disease, have become very rare and limb function is generally maintained. Metastatic risk presents the major problem, and in our series spread of the disease remained uncontrolled in 25% of cases. Further research is required in this area, and a better definition of the risk factors, especially with regard to histology, is needed. We suggest that the possibility of reinforcing treatment of those histological forms at high metastatic risk by the introduction of multidrug therapy after local treatment be investigated. Such studies can only be effectively conducted within the framework of a multicenter collaborative controlled clinical trial.
通过手术与常规放射治疗相结合的治疗方案（可能术前进行，术后肯定进行），成人软组织肉瘤的预后有了显著改善；局部复发是该疾病自然史中的主要因素，现已变得非常罕见，肢体功能通常得以保留。转移风险是主要问题，在我们的系列病例中，25%的病例疾病扩散仍未得到控制。这一领域需要进一步研究，尤其需要更好地界定风险因素，特别是在组织学方面。我们建议研究通过在局部治疗后引入多药疗法来加强对那些具有高转移风险的组织学类型的治疗的可能性。此类研究只能在多中心协作对照临床试验的框架内有效开展。
