van der Weyden M B, Fong H
Scand J Haematol. 1984 Oct;33(4):373-7. doi: 10.1111/j.1600-0609.1984.tb00710.x.
The basic ferritin content of red cells was measured in patients with untreated megaloblastic anaemia. The red cell ferritin of 10 patients with anaemia and vitamin B12 deficiency (mean 579, range 68-2616 attogram (ag)/cell); and of 8 patients with folate deficiency (mean 792, range 141-2373 ag/cell) were significantly elevated (P less than 0.001) compared with normal subjects (mean 10.7, range 4-47 ag/cell) and showed a significant correlation with pre-treatment levels of plasma ferritin and less so with percent transferrin saturation. Following vitamin replacement elevated red cell ferritin levels decreased during the period of reticulocytosis and was normal in 9 patients evaluated after 6 months. The magnitude of increase in red cell basic ferritin levels observed in untreated megaloblastic anaemia is comparable to that of subjects with idiopathic haemochromatosis and suggests that interpretation of this index for iron overload should take into consideration concomitant body folate or vitamin B12 status.
对未经治疗的巨幼细胞贫血患者测定了红细胞的基础铁蛋白含量。10例贫血且维生素B12缺乏患者的红细胞铁蛋白（均值579，范围68 - 2616阿托克（ag）/细胞）；8例叶酸缺乏患者的红细胞铁蛋白（均值792，范围141 - 2373 ag/细胞）与正常受试者（均值10.7，范围4 - 47 ag/细胞）相比显著升高（P小于0.001），且与治疗前血浆铁蛋白水平显著相关，与转铁蛋白饱和度百分比的相关性则较弱。维生素替代治疗后，红细胞铁蛋白水平在网织红细胞增多期下降，6个月后评估的9例患者恢复正常。未经治疗的巨幼细胞贫血患者中观察到的红细胞基础铁蛋白水平升高幅度与特发性血色素沉着症患者相当，这表明在解释该铁过载指标时应考虑同时存在的机体叶酸或维生素B12状态。
