Ballas S K, Saidi P, Constantino M
Am J Clin Pathol. 1976 Dec;66(6):953-7. doi: 10.1093/ajcp/66.6.953.
Ten patients with megaloblastic anemia had erythrocytes with reduced deformability. The mean half-life for erythrocyte filtration was 9.89 minutes in these patients, compared with 5,20 minutes in controls. The half-life was inversely related to the hemoglobin concentration. After adequate vitamin replacement therapy filtrability improved significantly. Two patients had thromboembolic disease, It is proposed that the reduced erythrocytic deformability reflects membrane rigidity that might ultimately lead to hemolysis.
10例巨幼细胞贫血患者的红细胞变形性降低。这些患者红细胞滤过的平均半衰期为9.89分钟，而对照组为5.20分钟。半衰期与血红蛋白浓度呈负相关。经过充分的维生素替代治疗后，滤过性显著改善。2例患者患有血栓栓塞性疾病。有人提出，红细胞变形性降低反映了膜刚性，这最终可能导致溶血。
