Reidy T J, Upshaw J D
South Med J. 1984 Dec;77(12):1582-4. doi: 10.1097/00007611-198412000-00027.
We have described six new patients accounting for seven episodes of agranulocytosis due to procainamide. Six episodes involved the slow-release oral preparation. With continued use of this convenient antiarrhythmic agent, it is important that physicians be alert to the possibility of agranulocytosis in febrile patients receiving procainamide. If agranulocytosis occurs, procainamide should be discontinued promptly and the fever should be treated aggressively with combination broad spectrum antibiotics.
我们描述了6例新患者，他们因普鲁卡因胺出现了7次粒细胞缺乏症发作。其中6次发作涉及口服缓释制剂。在持续使用这种方便的抗心律失常药物时，医生必须警惕接受普鲁卡因胺治疗的发热患者发生粒细胞缺乏症的可能性。如果发生粒细胞缺乏症，应立即停用普鲁卡因胺，并使用联合广谱抗生素积极治疗发热症状。
