血小板形状改变的激动剂特异性脱敏

Agonist-specific desensitization of shape change of platelets.

作者信息

Saito Y, Imada T, Shimada H, Kikuchi T, Suzuki H, Yamazaki H, Inada Y

出版信息

Thromb Res. 1984 Sep 15;35(6):689-95. doi: 10.1016/0049-3848(84)90271-8.

Abstract

Using scanning electron microscopy and light scattering we have investigated the shape change of bovine platelets. The extents of shape change obtained by ADP and 5-hydroxytryptamine(5HT) increased in dose-dependent manner, and the maximum obtained by these agonists were additive. The agonist-specific desensitization in shape change was observed with ADP, 5HT and thrombin. The extent of desensitization by pre-exposure to ADP was dependent upon the concentration of ADP. It was strongly indicated that receptors or their subsequent stimuli-transmission apparatus became unable to respond to further stimulation after the exposure to the initial stimulation.

摘要

我们使用扫描电子显微镜和光散射技术研究了牛血小板的形态变化。由二磷酸腺苷（ADP）和5-羟色胺（5HT）引起的形态变化程度呈剂量依赖性增加，并且这些激动剂所引起的最大变化程度具有加和性。观察到ADP、5HT和凝血酶在形态变化方面存在激动剂特异性脱敏现象。预先暴露于ADP所导致的脱敏程度取决于ADP的浓度。这有力地表明，受体或其后续的刺激传递装置在受到初始刺激后无法对进一步的刺激做出反应。