An electrophysiological study of 2-hexanone and 2,5-hexanedione neurotoxicity in rats.
作者信息
Nachtman J P, Couri D
出版信息
Toxicol Lett. 1984 Nov;23(2):141-5. doi: 10.1016/0378-4274(84)90118-8.
PMID:6506088
Abstract
n-Hexane and its metabolites are neurotoxic to animals and man. Studies have revealed a progressive neuropathy which affects the distal regions of motor and sensory peripheral nerves. This paper describes efforts to determine whether 2-hexanone or 2,5-hexanedione is more neurotoxic than 2-hexanone and that it first affects the distal axon. Concentrations of 20 mM produced no effects after 3 weeks but 40 mM increased distal latency after 2 weeks.
摘要
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