重复使用六氯酚处理期间，田鼠（Mus booduga）脑乙酰胆碱酯酶的催化潜力

Catalytic potential of field mouse Mus booduga brain acetylcholinesterase during repeated hexachlorophene treatment.

作者信息

Prasad G V, Rajendra W, Indira K

出版信息

Toxicol Lett. 1984 Nov;23(2):177-82. doi: 10.1016/0378-4274(84)90123-1.

Abstract

The catalytic efficiency of the field mouse (Mus booduga) brain acetyl cholinesterase (AChE, EC 3.1.1.7) was significantly (P less than 0.001) decreased probably through the reduction in the active site density of the enzyme content and elevation in the activation energy (delta E) requirements during repeated hexachlorophene (HCP) treatment. Fall in the activity potential of AChE may account for the interference of HCP or its reactive metabolites with the acetylcholine (ACh)-AChE system and deserve consideration in contributing to the neurotoxicity.

摘要

在反复使用六氯酚（HCP）治疗期间，田鼠（Mus booduga）脑乙酰胆碱酯酶（AChE，EC 3.1.1.7）的催化效率显著降低（P<0.001），这可能是由于酶含量的活性位点密度降低以及活化能（ΔE）需求增加所致。AChE活性电位的下降可能解释了HCP或其活性代谢产物对乙酰胆碱（ACh）-AChE系统的干扰，这在导致神经毒性方面值得考虑。