Pacini F, Lari R, Taddei D, Grasso L, Martino E, Baschieri L, Pinchera A
Tumori. 1984 Oct 31;70(5):417-9. doi: 10.1177/030089168407000505.
It is now well accepted that serum thyroglobulin (Tg) determination is a specific marker of disease activity in well-differentiated thyroid cancer after total thyroidectomy. In this study we examined 15 thyroidectomized patients with metastases from medullary thyroid cancer and 10 patients with metastases from undifferentiated thyroid cancer, to determine whether serum Tg measurement could be useful also in these types of thyroid tumors. In contrast with differentiated thyroid cancer, which had high levels of circulating serum Tg, patients with medullary and undifferentiated thyroid cancer had undetectable or low levels of serum Tg. Thus, serum Tg measurements are not useful in the diagnosis of metastatic disease in these patients.
目前人们普遍认为，在全甲状腺切除术后，血清甲状腺球蛋白（Tg）测定是分化型甲状腺癌疾病活动的特异性标志物。在本研究中，我们检查了15例甲状腺髓样癌转移的甲状腺切除患者和10例未分化甲状腺癌转移的患者，以确定血清Tg测量在这些类型的甲状腺肿瘤中是否也有用。与循环血清Tg水平较高的分化型甲状腺癌不同，甲状腺髓样癌和未分化甲状腺癌患者的血清Tg水平检测不到或很低。因此，血清Tg测量对这些患者转移性疾病的诊断没有帮助。
