Khristova Kh, Ninov N V, Dilovska Kh
Vet Med Nauki. 1984;21(7-8):57-61.
Hydrolysate was obtained through enzyme hydrolysis from waste residual fibrin in the production of hyperimmune swine blood. Fibrin hydrolysate and gelatose in 2.5 : 1.5 ratio were tested as protective medium for the freeze-drying of VR2 vaccine against swine erysipelas. It was found that the freeze-drying of the vaccine with the addition of the hydrolysate-gelatose medium at the rate of 4-5 per cent of the vaccine volume met the requirements of the standard for sterility, innocuity, vaccinal titer, and residual moisture.
水解产物是通过酶解从高免猪血液生产过程中的废弃残余纤维蛋白中获得的。以2.5:1.5的比例将纤维蛋白水解产物和明胶用作冻干猪丹毒VR2疫苗的保护介质进行测试。结果发现,添加占疫苗体积4-5%的水解产物-明胶介质对疫苗进行冻干,符合无菌、无毒、疫苗效价和残留水分标准的要求。