Semenova I A, Pen'kovskaia N P
Vopr Med Khim. 1984 Jul-Aug;30(4):94-7.
Activity of purine phosphoribosyl transferases was studied in 11 patients with Lesch-Nyhan syndrome before and within 1 or 3 months after beginning of the purine-free diet treatment. The enzymatic activity tended to normalization within 1 month after the dietary treatment but the ratio of the enzymes activity was deteriorated within the subsequent 3 months of treatment. A positive clinical effect of the purine-free diet was noted.
在11例莱施-奈恩综合征患者开始无嘌呤饮食治疗前以及治疗开始后1个月或3个月内，对嘌呤磷酸核糖基转移酶的活性进行了研究。饮食治疗后1个月内酶活性趋于正常化，但在随后的3个月治疗中酶活性比例恶化。观察到无嘌呤饮食有积极的临床效果。
