Matov V, Savov G, Brailski Kh, Velev G
Vutr Boles. 1984;23(4):39-42.
A parallel study on histamine concentration and morphology of biopsy from gastric mucosa, was carried out with 60 patients with duodenal ulcer, prior to and post stimulation with pentagastrin--6 micrograms/kg. Histamine was spectrofluorimetrically determined. The functional-morphological changes that developed were followed up on 15, 30 and 60 min after the stimulation. They were a functional character and were due to disturbed microcirculation of the gastric mucosa: edema, venous stasis and leukopedesis. The latter were progressively increased within the course of 1 hour after the stimulation. The histamine-mobilizing effect of pentagastrin was manifested with a short-term decrease, followed by a considerable increase of histamine content in gastric mucosa of the patients with duodenal ulcer.
对60例十二指肠溃疡患者在注射6微克/千克五肽胃泌素刺激前后，进行了胃黏膜活检组织中组胺浓度与形态学的平行研究。采用荧光分光光度法测定组胺。在刺激后15、30和60分钟对出现的功能形态学变化进行随访。这些变化具有功能特征，是由于胃黏膜微循环紊乱所致：水肿、静脉淤滞和白细胞游出。后者在刺激后1小时内逐渐增加。五肽胃泌素的组胺动员作用表现为十二指肠溃疡患者胃黏膜中组胺含量短期下降，随后显著增加。
