Subbotina L S, Beliavskaia N A, Matiukhina L V, Kopylova L M, Kul'chitskaia T I
Zh Mikrobiol Epidemiol Immunobiol. 1984 Sep(9):71-4.
The immunization of donors with dried, purified, inactivated and concentrated cell-culture tick-borne encephalitis vaccine, produced at the Institute of Poliomyelitis and Viral Encephalitides in Moscow, has been carried out with the aim of obtaining immune raw material for the production of specific donor immunoglobulin. The high immunogenic potency and low reactogenicity of the vaccine, introduced in 2 injections at an interval of 6 months, have been confirmed. Immunization in 2 injections has proved to be as effective as that achieved by 3 injections. The expediency of the immunization of regularly bled donors has been established: hemagglutinin titers in these donors have been found to be significantly higher than in a group of persons never bled before. The optimum time for taking blood has been determined: 3 weeks for regularly bled donors and 2 weeks for donors bled for the first time. Blood may be taken again 2 months after the first bleeding without booster immunization and 2 weeks after the third injection of the vaccine.
为获取用于生产特定供体免疫球蛋白的免疫原料，对供体使用了由莫斯科脊髓灰质炎和病毒性脑炎研究所生产的干燥、纯化、灭活及浓缩的细胞培养蜱传脑炎疫苗进行免疫。该疫苗分两次注射，间隔6个月，其高免疫原性和低反应原性已得到证实。两次注射免疫已证明与三次注射同样有效。已确定定期采血供体免疫的合理性：发现这些供体的血凝素滴度显著高于一组此前从未采血的人。已确定最佳采血时间：定期采血供体为3周，首次采血供体为2周。首次采血后2个月且无需加强免疫时可再次采血，疫苗第三次注射后2周也可再次采血。
