胆碱在体内通过血视网膜屏障和血脑屏障的转运。

Choline transport through the blood-retinal and the blood-brain barrier in vivo.

作者信息

Karlsson C, Mäepea O, Alm A

出版信息

Acta Ophthalmol (Copenh). 1984 Oct;62(5):763-6. doi: 10.1111/j.1755-3768.1984.tb05804.x.

DOI:10.1111/j.1755-3768.1984.tb05804.x

Abstract

The uptake index method was used to study retinal and cerebral uptake of [14H]labelled choline in rats. In both tissues a saturable uptake was observed. This uptake was significantly inhibited by 10-20 mM unlabelled choline chloride as well as by 10 mM hemicholinium-3. It is concluded that choline passes the blood-retinal barrier by a carrier-mediated transport system similar to that in the blood-brain barrier.

摘要

采用摄取指数法研究了大鼠视网膜和脑对[14H]标记胆碱的摄取。在这两种组织中均观察到可饱和摄取。10 - 20 mM未标记的氯化胆碱以及10 mM的半胱氨酸-3可显著抑制这种摄取。得出的结论是，胆碱通过类似于血脑屏障中的载体介导转运系统穿过血视网膜屏障。