Helgesen K G, Kristiansen O, Refsum H
Acta Pharmacol Toxicol (Copenh). 1984 Oct;55(4):303-7. doi: 10.1111/j.1600-0773.1984.tb01986.x.
A new antiarrhythmic drug, droxicainide, was compared with lidocaine in order to evaluate droxicainide's effect on heart muscle. Dose-response curves for electrophysiological and mechanical effects of the two drugs on spontaneously beating atria, electrically stimulated atria and papillary muscles isolated from rats were obtained. After increasing doses of both droxicainide and lidocaine sinus node automaticity decreased, atrial and ventricular excitability and contractile force decreased and refractoriness increased. The effects of the two drugs on atrial and ventricular muscle were qualitatively and quantitatively the same, but droxicainide was less potent. The results fit well with the concept that droxicainide is a class 1 anti-arrhythmic drug.
一种新型抗心律失常药物——多西卡胺，与利多卡因进行了比较，以评估多西卡胺对心肌的作用。获得了两种药物对大鼠离体自搏心房、电刺激心房和乳头肌的电生理和机械效应的剂量反应曲线。多西卡胺和利多卡因剂量增加后，窦房结自律性降低，心房和心室兴奋性及收缩力降低，不应期延长。两种药物对心房和心室肌的作用在定性和定量上相同，但多西卡胺的效力较弱。这些结果与多西卡胺是Ⅰ类抗心律失常药物的概念非常吻合。
