Kristiansen O, Refsum H, Hotvedt R
Clin Physiol. 1982 Aug;2(4):299-306. doi: 10.1111/j.1475-097x.1982.tb00034.x.
Clinical trials suggest that sulphinpyrazone reduces the incidence of sudden death in patients having suffered a myocardial infarction. To investigate possible direct antiarrhythmic properties of sulphinpyrazone, we carried out experiments on spontaneously beating and electrically stimulated isolated rat atrial preparations. Dose-response curves for electrophysiological and mechanical effects of sulphinpyrazone were obtained. Increasing doses of sulphinpyrazone decreased the spontaneous atrial frequency, prolonged the sinus node recovery time after overdrive pacing, slightly increased the electrical threshold for excitation and decreased the contractile force. Although the mechanism by which sulphinpyrazone may reduce the incidence of sudden cardiac death is still not settled, the present study demonstrates direct electrophysiological and mechanical effects of the drug at high concentrations.
临床试验表明，磺吡酮可降低心肌梗死患者猝死的发生率。为研究磺吡酮可能的直接抗心律失常特性，我们对自发搏动和电刺激的离体大鼠心房标本进行了实验。获得了磺吡酮电生理和机械效应的剂量反应曲线。磺吡酮剂量增加时，可降低心房自发频率，延长超速起搏后的窦房结恢复时间，略微提高兴奋的电阈值，并降低收缩力。尽管磺吡酮降低心源性猝死发生率的机制仍未明确，但本研究证明了该药物在高浓度时的直接电生理和机械效应。
