O'Connor C R, Rubinow A, Cohen A S
Am J Med. 1984 Dec;77(6):981-6. doi: 10.1016/0002-9343(84)90173-6.
Amyloidosis is rarely considered in the differential diagnosis of breast masses. During the past six years, 27 women with primary (24) and multiple myeloma-associated (three) amyloidosis (AL amyloid) were evaluated at our center. In five of these patients, amyloid was demonstrated on microscopic examination of breast tissue. The clinical presentations were similar to fibrocystic breast disease in two cases and malignancy in two others. Amyloidosis of the breast may be more common than previously recognized, especially considering the predilection of amyloid for depositing around fat cells. Therefore, pathologic examination of nonmalignant breast tissue should include Congo red staining and viewing under polarized light.
淀粉样变性在乳腺肿块的鉴别诊断中很少被考虑。在过去六年中，我们中心评估了27例原发性（24例）和多发性骨髓瘤相关（3例）淀粉样变性（AL淀粉样变性）的女性患者。在其中5例患者的乳腺组织显微镜检查中发现了淀粉样物质。其中2例患者的临床表现与纤维囊性乳腺病相似，另外2例与恶性肿瘤相似。乳腺淀粉样变性可能比之前认为的更为常见，尤其是考虑到淀粉样物质倾向于沉积在脂肪细胞周围。因此，对非恶性乳腺组织的病理检查应包括刚果红染色和偏振光观察。
