Pierard G E, Cornil F, Lapiere C M
Am J Dermatopathol. 1984 Oct;6(5):491-7. doi: 10.1097/00000372-198410000-00013.
The structure of the skin and the pattern of alteration in chronic ulcerations associated with deficiency of prolidase have been studied superficially in the past. We examined histologically several biopsies taken from apparently normal skin and from ulcerations afflicting a young woman with such a syndrome. Deposits of amyloid were found within the walls of medium-sized vessels and occasionally occluding their lumens. Impaired cutaneous microcirculation resulting from statis, moderate vasculitis, and abnormal structure of the dermis may be responsible for the regional preponderance of deposits of amyloid and ulcerations in the legs.
过去曾对与脯氨酰肽酶缺乏相关的慢性溃疡的皮肤结构和变化模式进行过初步研究。我们对取自一名患有该综合征的年轻女性的明显正常皮肤和溃疡处的几块活检组织进行了组织学检查。在中等大小血管壁内发现了淀粉样蛋白沉积，偶尔会阻塞管腔。由于血流淤滞、中度血管炎和真皮结构异常导致的皮肤微循环受损，可能是腿部淀粉样蛋白沉积和溃疡区域优势的原因。
