Drobinski G, Komajda M, Lechat P
Ann Cardiol Angeiol (Paris). 1984 Nov;33(7):475-9.
ARL 115 has vasodilator and positive inotropic properties which justify its use in heart failure. The effects of this drug were studied in 8 patients with advanced myocardial failure (7 cases of primary cardiomyopathy and 1 case of ischaemic cardiomyopathy) undergoing diagnostic cardiac catheterization, 15 minutes after angiocardiography. The cardiac output pressures were measured and the M mode electrocardiogram was recorded under basal conditions and following an infusion of 1 mg/kg of ARL 115 over 10 minutes. An improvement was observed in 7 cases, with an increase in the cardiac output and a decrease in the left ventricular diastolic pressure (p less than 0.05). There was no significant modification in the heart rate and there were no side effects. In one case, an abrupt fall in the diastolic pressure led to a decrease in the cardiac output. The arterial and venous vasodilator properties were demonstrated in every case, but a positive inotropic action (increase in the dp/dtmax and modification of the end-diastolic pressure: dimension ratio) was demonstrated in only two cases. The absence of positive inotropic action in the 6 other cases could be due to the advanced myocardial deterioration in these patients or to a delay in the positive inotropic effect in relation to the vasodilator effect.
ARL 115具有血管舒张和正性肌力特性，这使其在心力衰竭治疗中具有应用价值。在8例晚期心肌衰竭患者（7例原发性心肌病和1例缺血性心肌病）中研究了该药物的作用，这些患者在心血管造影术后15分钟接受诊断性心导管检查。在基础状态下以及在10分钟内输注1mg/kg的ARL 115后，测量心输出量压力并记录M型心电图。7例患者病情有所改善，心输出量增加，左心室舒张压降低（p<0.05）。心率无明显变化，也无副作用。1例患者舒张压突然下降导致心输出量减少。在每个病例中均显示出动脉和静脉血管舒张特性，但仅在2例中显示出正性肌力作用（dp/dtmax增加和舒张末期压力：尺寸比改变）。其他6例患者未出现正性肌力作用可能是由于这些患者心肌严重恶化，或者是正性肌力作用相对于血管舒张作用延迟出现。
