Brogard J M, Arnaud J P, Blickle J F, Lavillaureix J
Antimicrob Agents Chemother. 1984 Sep;26(3):428-30. doi: 10.1128/AAC.26.3.428.
Apalcillin was administered intravenously as a single 1-g dose on day 8 after surgery to 10 cholecystectomized patients with T-tube drainage. A peak of 2,093 +/- standard error of the mean 859 micrograms/ml of bile was attained at 3 h after dosage. Biliary recovery over a 12-h period amounted to 12.2% of the dose. In 20 patients undergoing biliary surgery, apalcillin concentrations 1 h after a 1-g dose were 65.5 +/- 5.0, 3,680 +/- 551, and 2,552 +/- 627 micrograms/ml in serum, choledochal bile, and gallbladder bile, respectively.
在术后第8天，对10例接受T管引流的胆囊切除患者静脉注射1克单剂量阿帕西林。给药后3小时，胆汁中阿帕西林浓度达到峰值，平均为2093±859微克/毫升（均值标准误）。12小时内胆汁中的药物回收率为给药剂量的12.2%。在20例接受胆道手术的患者中，静脉注射1克剂量阿帕西林1小时后，血清、胆总管胆汁和胆囊胆汁中的药物浓度分别为65.5±5.0、3680±551和2552±627微克/毫升。
