Zaĭrat'iants O V
Arkh Patol. 1984;46(9):87-91.
An 18-year-old female patient is described, suffering from the syndrome of the immunoendocrine insufficiency, status thymicolymphaticus with hyperplasia of the reticulo-epithelial cells and Hassall's corpuscles of the thymus, generalized hyperplasia of the lymphoid tissue and adrenal hypoplasia. When pregnant, she developed a giantism of the mammary glands with a high blood prolactin level. Death occurred several hours after surgery for artificial abortion from acute adrenal insufficiency resulting from adrenal hypoplasia possibly aggravated by the use of parlodel. Eosinophilic (prolactin-somatotrophic) adenohypophyseal hyperplasia which was much higher than that expected in pregnancy evidenced the role of both prolactin and somatotrophic hormone in the pathogenesis of the mamma giantism. The morphological manifestations of the latter were proliferation of the intralobular connective tissue and end ducts and marked interstitial edema of the mammary glands.
本文描述了一名18岁女性患者，患有免疫内分泌功能不全综合征、胸腺淋巴体质，伴有胸腺网状上皮细胞和哈氏小体增生、淋巴组织全身性增生及肾上腺发育不全。怀孕时，她出现乳腺巨大症，催乳素水平升高。因肾上腺发育不全导致急性肾上腺功能不全，可能因使用溴隐亭而加重，人工流产手术后数小时死亡。嗜酸性（催乳素-生长激素）腺垂体增生程度远高于孕期预期，证明催乳素和生长激素在乳腺巨大症发病机制中均起作用。乳腺巨大症的形态学表现为小叶内结缔组织和终末导管增生以及乳腺明显的间质水肿。
