Low L C, Lam B C, Wong W T, Chan-Lui W Y, Yeung C Y
Aust Paediatr J. 1984 Aug;20(3):225-8. doi: 10.1111/j.1440-1754.1984.tb00084.x.
Despite adequate treatment, mortality and morbidity were high among the 13 cases of Salmonella meningitis in this series. Chloramphenicol, being a bacteriostatic agent against Salmonella species, is not a suitable antibiotic for the treatment of Salmonella meningitis. Treatment for 4-6 weeks is recommended with use of an antibiotic capable of achieving an adequate bactericidal concentration in the cerebrospinal fluid such as moxalactam. Intraventricular antibiotic treatment should be considered if there is a delay in the eradication of the Salmonella organisms from the cerebrospinal fluid after starting treatment.
尽管进行了充分治疗，但该系列13例沙门氏菌脑膜炎患者的死亡率和发病率仍很高。氯霉素作为一种针对沙门氏菌属的抑菌剂，并非治疗沙门氏菌脑膜炎的合适抗生素。建议使用能在脑脊液中达到足够杀菌浓度的抗生素，如羟羧氧酰胺菌素，进行4至6周的治疗。如果开始治疗后从脑脊液中根除沙门氏菌的过程出现延迟，则应考虑进行脑室内抗生素治疗。
