一元羧酸的肾脏转运。近端小管中乳酸转运系统的异质性。
Renal transport of monocarboxylic acids. Heterogeneity of lactate-transport systems along the proximal tubule.
作者信息
Jørgensen K E, Sheikh M I
出版信息
Biochem J. 1984 Nov 1;223(3):803-7. doi: 10.1042/bj2230803.
Abstract
The characteristics of D- and L-lactate transport in luminal-membrane vesicles derived from whole cortex, from the pars convoluta and from the pars recta of rabbit kidney proximal tubule were studied. It was found that uptake of both isomers in vesicles from whole cortex occurred by means of dual electrogenic transport systems, namely a low-affinity system and a high-affinity system. Uptake of both isomers in vesicles from the pars recta was strictly Na+-dependent and is mediated via a single high-affinity common transport system. Vesicles from the pars convoluta contained a cation-dependent but Na+-unspecific low-affinity common transport system for these compounds. The physiological importance of this system is briefly discussed.
摘要
研究了来自兔肾近端小管全皮质、曲部和直部的管腔膜囊泡中 D-和 L-乳酸转运的特征。发现全皮质囊泡中两种异构体的摄取是通过双电转运系统进行的，即低亲和力系统和高亲和力系统。直部囊泡中两种异构体的摄取严格依赖 Na+，并通过单一的高亲和力共同转运系统介导。曲部囊泡含有一种阳离子依赖性但 Na+非特异性的低亲和力共同转运系统来转运这些化合物。简要讨论了该系统的生理重要性。
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