钙调蛋白拮抗剂N-（6-氨基己基）-5-氯-1-萘磺酰胺（W-7）使小鼠皮肤中佛波酯受体数量减少。
Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.
作者信息
Nishino H, Fujiki H, Suganuma M, Horiuchi T, Iwashima A, Sugimura T
出版信息
Biochem Biophys Res Commun. 1984 Nov 14;124(3):726-30. doi: 10.1016/0006-291x(84)91018-0.
PMID:6508780
Abstract
A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 mumoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-O-tetra-decanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.
摘要
一种钙调蛋白拮抗剂，N-(6-氨基己基)-5-氯-1-萘磺酰胺（W-7），以剂量和时间依赖性方式减少了小鼠皮肤中佛波酯受体的数量。在局部应用30微摩尔W-7后立即出现减少，5分钟后达到最大值86%。12-O-十四烷酰佛波醇-13-乙酸酯特异性结合的减少可以解释W-7在小鼠皮肤中的抗肿瘤促进活性。
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