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[Effect of adrenaline on nucleotide composition and the degree of DNA methylation in the canine myocardium].

作者信息

Kliasheva R I, Vasil'ev Zh K

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(10):31-3.

PMID:6509129
Abstract

Nucleotide composition and changes of 5-methylcytosine content (m5C) in DNA isolated from male-dogs' cardiac muscle (stomach) under the influence of adrenalin have been studied. After slow intravenous injection of adrenalin in extremal doses (7 mg during 5 days) quantity of m5C in DNA decreases in 1,2 times in comparison with the control. Is has been suggested that the decrease of DNA methylation by cytosine is possible as a result of increase of enzyme activity demethylizing DNA by cytosine and (or) inactivation of methilase specifically methylizing DNA by cytosine.

摘要

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Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(10):31-3.
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