[几种制剂在不同脑缺氧模型中的比较研究]
[Comparative study of several preparations in different models of cerebral hypoxia].
作者信息
Ivanova I A, Bobkov Iu G
出版信息
Biull Eksp Biol Med. 1984 Nov;98(11):567-70.
The antihypoxic effects of gutimine, piracetam, sodium hydroxybutyrate and lithium hydroxybityrate were studied on different models of brain hypoxia. All the drugs under study produced a remarkable antihypoxic effect in experimental asphyxic hypoxia, increasing brain resistance to oxygen deficiency and rapidly restituting brain function. Drug pretreatment of the animals with carotid artery occlusion raised the number of animals which survived 24 h after the operation. GABA salts appeared the most effective. Sodium hydroxybutyrate increased the lifespan of rats under histotoxic hypoxia.
研究了胍立莫司、吡拉西坦、羟基丁酸钠和羟基丁酸锂在不同脑缺氧模型上的抗缺氧作用。所有研究的药物在实验性窒息性缺氧中均产生显著的抗缺氧作用，增强脑对缺氧的耐受性并迅速恢复脑功能。对动物进行颈动脉闭塞术前用药可提高术后存活24小时的动物数量。GABA盐似乎最为有效。羟基丁酸钠可延长组织中毒性缺氧大鼠的存活时间。
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