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[吗啡辨别性和镇痛作用的比较特征]

[Comparative characteristics of the discriminative and analgesic effects of morphine].

作者信息

Patkina N A, Zvartau E E

出版信息

Biull Eksp Biol Med. 1984 Nov;98(11):580-1.

PMID:6509175
Abstract

Experiments on mice were made to study and compare the discriminative and analgesic effects of morphine. The time-course of tolerance to the drug effects was found to be different. The Schild method permitted one to determine significantly different characteristics of naloxone antagonism (pA2) as regards the analgesic and discriminative effects of morphine. The data obtained attest to the different mechanisms of the analgesic and discriminative effects of morphine.

摘要

进行了小鼠实验以研究和比较吗啡的辨别和镇痛作用。发现对药物作用的耐受性的时间进程有所不同。Schild方法能够确定纳洛酮拮抗作用（pA2）在吗啡镇痛和辨别作用方面的显著不同特征。所获得的数据证明了吗啡镇痛和辨别作用的不同机制。

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