Nazarevskaia G D, Dobrokhotov V N, Reznikov K Iu
Biull Eksp Biol Med. 1984 Dec;98(12):731-3.
The mitotic and pyknotic indices were counted in the local germinative zones of Ammon's horn and dentate gyrus of normal mice from embryonic day 18 (ED 18) to postnatal day 60 (PD 60). The local germinative zone of Ammon's horn (the suprafimbrial zone) forms from ED 16 but the first pyknoses appear in it from ED 20. After a rapid increase of the mitotic and pyknotic indices with a maximum reached on PD 3 there is a sharp decrease of their values corresponding to the reduction of the suprafimbrial zone. The local germinative zone of the dentate gyrus is generated from ED 14, however pyknoses appear from PD 1. The greatest values of the mitotic and pyknotic indices fall within PD 3. Later on the values of both indices gradually decrease, however, they are sufficiently pronounced even on PD 60. It is suggested that the mitotic death by means of pyknotic degeneration is connected with elimination of the spontaneous mutations of glial precursors in the germinative zones of the brain.
在正常小鼠从胚胎第18天（ED 18）到出生后第60天（PD 60）期间，对海马角和齿状回的局部生发区进行有丝分裂指数和固缩指数计数。海马角的局部生发区（伞上区）从ED 16开始形成，但从ED 20开始出现首批固缩现象。在有丝分裂指数和固缩指数迅速增加并在PD 3达到最大值后，其值急剧下降，这与伞上区的缩小相对应。齿状回的局部生发区从ED 14开始形成，然而固缩现象从PD 1开始出现。有丝分裂指数和固缩指数的最大值出现在PD 3。之后，这两个指数的值逐渐下降，不过即使在PD 60时它们仍然较为明显。有人提出，通过固缩性退变的有丝分裂性死亡与消除脑生发区神经胶质前体细胞的自发突变有关。
