Keeling D H, Sampson C B
Br J Radiol. 1984 Dec;57(684):1091-6. doi: 10.1259/0007-1285-57-684-1091.
Details of reports to the UK Adverse Reaction Reporting Scheme for the years 1977-1983 are given. These show a changing pattern since earlier reports, in part due to the discontinuance of older radiopharmaceuticals and changes in quality control measures, but also to the introduction of methylene diphosphonate for bone imaging which has accounted for nearly half of our more recent reports. Colloids for reticulo-endothelial (liver) scans account for about one third of this series. The great majority of reactions are of an idiosyncratic hypersensitive nature and none due to sterility problems or pyrogens. Accurate incidence figures are difficult to obtain but including even the trivial forms of reaction, we estimate a reaction rate of between 1:1000 and 1:10,000 in vivo nuclear medicine procedures, a figure considerably higher than most previous surveys have suggested.
文中给出了1977年至1983年向英国药品不良反应报告计划提交报告的详细情况。这些报告显示，自早期报告以来情况有所变化，部分原因是旧的放射性药物停用以及质量控制措施的改变，但也由于用于骨显像的亚甲基二膦酸盐的引入，在我们最近的报告中，它占了近一半。用于网状内皮（肝脏）扫描的胶体占该系列报告的约三分之一。绝大多数反应属于特异质过敏性质，没有因无菌问题或热原引起的反应。准确的发生率数据难以获得，但即使包括最轻微的反应形式，我们估计在体内核医学程序中的反应率为1:1000至1:10000之间，这一数字大大高于以往大多数调查所表明的数字。
