Shani J, Atkins H L, Wolf W
Semin Nucl Med. 1976 Jul;6(3):305-28. doi: 10.1016/s0001-2998(76)80010-4.
This review covers the side effects and adverse reactions to radiopharmaceuticals that were reported in the literature over the past 25 years. The information published prior to 1970 is sporadic, but due to the increased utilization of nuclear medicine procedures and the recognition that radiopharmaceuticals may have pharmacologic side effects, a registry has existed since 1971 to tabulate information on such effects. This survey is medical, rather than pharmaceutical in emphasis and so the adverse reactions are classified according to the target-organ systems involved rather than according to the specific radionuclides or to pharmaceuticals. If any of the radiopharmaceuticals of present or past use are not mentioned in this review, it is because no reports on their side effects were retrived by us. Hopefully, the organized registry system suggested by the Society of Nuclear Medicine (SNM) will enable a more complete recording of side effects from radiopharmaceuticals in the future.
本综述涵盖了过去25年文献中报道的放射性药物的副作用和不良反应。1970年以前发表的信息是零散的，但由于核医学程序的使用增加以及认识到放射性药物可能有药理副作用，自1971年起设立了一个登记处来汇总此类效应的信息。本调查重点在于医学方面，而非药学方面，因此不良反应是根据所涉及的靶器官系统进行分类，而非根据特定的放射性核素或药物进行分类。如果本综述未提及目前或过去使用的任何放射性药物，那是因为我们未检索到关于其副作用的报告。希望核医学协会（SNM）建议的有组织的登记系统能在未来更全面地记录放射性药物的副作用。
