Laplante P, Vanasse M, Michaud J, Geoffroy G, Brochu P
Can J Neurol Sci. 1984 Nov;11(4 Suppl):561-4. doi: 10.1017/s0317167100035046.
Several authors have recently reported a neurological disorder associated with chronic vitamin E deficiency in man. Except in one patient, this deficiency has always been secondary to an underlying disease resulting in lipid malabsorption. We report a second case of such a neurological syndrome in a patient in whom vitamin E deficiency was an isolated finding. The clinical picture in our patient was characterized by a diffuse muscle weakness most prominent distally and in the lower limbs, generalized areflexia, a decrease in proprioception and vibration sense and slight limb and gait ataxia. His condition improved on alpha tocopherol therapy so that it is very likely that vitamin E deficiency is responsible for his neurological deficit. Since in our patient as well as in several other reported cases this condition has been treatable, it is important that this syndrome be recognized in children presenting a suggestive clinical picture even if they do not have lipid malabsorption.
最近有几位作者报道了一种与人类慢性维生素E缺乏相关的神经障碍。除了一名患者外，这种缺乏总是继发于导致脂质吸收不良的潜在疾病。我们报告了第二例这种神经综合征病例，该患者的维生素E缺乏是一个独立发现。我们患者的临床表现为弥漫性肌肉无力，最明显的是在远端和下肢，全身性反射消失，本体感觉和振动觉减退，以及轻微的肢体和步态共济失调。他的病情在α-生育酚治疗后有所改善，因此很可能是维生素E缺乏导致了他的神经功能缺损。由于在我们的患者以及其他几例报告的病例中，这种情况是可治疗的，所以即使没有脂质吸收不良，对于出现提示性临床表现的儿童来说，认识到这种综合征很重要。
