晚期乳腺癌负荷剂量他莫昔芬的临床评估
A clinical assessment of loading dose tamoxifen for advanced breast carcinoma.
作者信息
Ribeiro G G, Wilkinson P M
出版信息
Clin Oncol. 1984 Dec;10(4):363-7.
PMID:6509818
Abstract
Seventy patients with advanced breast carcinoma were treated with a loading dose regimen of 160 mg Tamoxifen on day 1 followed by a maintenance dose of 20 mg daily from day 2 onwards. Compliance was 100% and only 3 patients developed mild side effects. In 27% regression of disease was observed within 1 month and in 57% within 2 months. This regimen is recommended for routine clinical use.
摘要
70例晚期乳腺癌患者在第1天接受160mg他莫昔芬的负荷剂量治疗，从第2天起每天接受20mg的维持剂量治疗。依从性为100%，只有3例患者出现轻度副作用。27%的患者在1个月内观察到疾病消退，57%的患者在2个月内观察到疾病消退。推荐该方案用于常规临床治疗。
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