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冷停搏液心肌保护的临床与实验研究

Clinical and experimental study of cold cardioplegic myocardial protection.

作者信息

Szabó Z, Juhász-Nagy A, Lengyel I, Moravcsik E, Papp L

出版信息

Cor Vasa. 1984;26(5):336-44.

PMID:6509990
Abstract

The authors used a multi-dimensional approach to the study of the effects of intra-operative myocardial protection; the results of three series of investigations are reported. First, conditions underlying the effectiveness of the authors' modified cardioplegic solution were studied by laboratory and histological methods in ex vivo guinea pig hearts. Evidence is presented for the detrimental effects of catecholamines and the beneficial action of inosine. The second part of the report deals with problems of effective myocardial cooling in partially ischaemic canine hearts, investigated by infrared thermographic examinations of temporal and spatial thermal distribution over the entire visible cardiac surface. At last the authors present the result of their complex intra- and postoperative enzyme analysis combined with mathematical evaluation (cluster analysis in a group of patients suffering from ischaemic heart disease).

摘要

作者采用多维度方法研究术中心肌保护的效果;报告了三个系列研究的结果。首先,通过实验室和组织学方法,在离体豚鼠心脏中研究了作者改良心脏停搏液有效性的潜在条件。文中给出了儿茶酚胺的有害作用和肌苷的有益作用的证据。报告的第二部分探讨了部分缺血犬心脏中有效心肌降温的问题,通过对整个可见心脏表面的时间和空间热分布进行红外热成像检查来研究。最后,作者展示了他们在一组缺血性心脏病患者中进行的综合术中和术后酶分析及数学评估(聚类分析)的结果。

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