有机化学品对大鼠和鱼类急性毒性的定量比较。

Quantitative comparisons of acute toxicity of organic chemicals to rat and fish.

作者信息

Janardan S K, Olson C S, Schaeffer D J

出版信息

Ecotoxicol Environ Saf. 1984 Dec;8(6):531-9. doi: 10.1016/0147-6513(84)90013-7.

Abstract

Relationships between the acute toxicity of chemicals to fish (LC50) and rat (LD50) were analyzed using a Model II regression analysis after logarithmic transformation. (Model II regression assumes errors in both variables.) Significant correlations were found among bluegill and fathead minnow LC50S and rat LD50 values for the "priority pollutants." Fathead minnow and bluegill LC50S for 48 pesticides were highly correlated. No correlations were found between fish and rat for carbamate plus organophosphate pesticides. Correlations were obtained among all species for the combined priority pollutant plus pesticide data and for chlorinated pesticides.

摘要

在对数转换后，使用II型回归分析（II型回归假定两个变量都存在误差）分析了化学品对鱼类的急性毒性（半数致死浓度，LC50）与对大鼠的急性毒性（半数致死剂量，LD50）之间的关系。对于“优先污染物”，在蓝鳃太阳鱼和黑头呆鱼的LC50值与大鼠的LD50值之间发现了显著相关性。48种农药的黑头呆鱼和蓝鳃太阳鱼LC50值高度相关。对于氨基甲酸酯类农药和有机磷酸酯类农药，未发现鱼类与大鼠之间存在相关性。对于优先污染物与农药的综合数据以及氯化农药，在所有物种之间均获得了相关性。