Labar B, Stavljenić A, Jusufhodzić L
Enzyme. 1984;32(3):178-83. doi: 10.1159/000469472.
The red cell pyruvate kinase (PK) activity, KM for phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP), and thermostability properties were studied in patients with acute leukemias. The acquired PK defect was found in patients with acute myeloid leukemia, while it was normal in acute non-myeloid leukemia enzyme kinetic tests. PK abnormality was expressed in 17 patients as deficient PK activity, in 15 patients as decreased enzyme thermostability, and in 11 patients as altered PK affinity for ADP.
对急性白血病患者的红细胞丙酮酸激酶（PK）活性、磷酸烯醇丙酮酸（PEP）和二磷酸腺苷（ADP）的米氏常数（KM）以及热稳定性进行了研究。在急性髓系白血病患者中发现了获得性PK缺陷，而在急性非髓系白血病酶动力学试验中其结果正常。17例患者表现为PK活性缺乏，15例患者表现为酶热稳定性降低，11例患者表现为PK对ADP的亲和力改变，这些情况均显示出PK异常。
