血红素在造血细胞分化早期体内作用的特异性。
Specificity of hemin action in vivo at early stages of hematopoietic cell differentiation.
作者信息
Monette F C, Holden S A, Sheehy M J, Matzinger E A
出版信息
Exp Hematol. 1984 Nov;12(10):782-7.
PMID:6510480
Abstract
The effects of a single injection of hemin on murine marrow BFU-E and CFU-S were assessed to determine whether hemin is as effective in augmenting primitive (day 7) BFU-E levels in situ as it is in vitro and to assess hemin's action on transplantable pluripotent stem cells (CFU-S). The results show that hemin exerts a cell-specific enhancement of both BFU-E marrow levels and cell cycling within 6 h of its administration in vivo. No such effect on CFU-S was observed.
摘要
评估单次注射氯高铁血红素对小鼠骨髓爆式红系集落形成单位（BFU-E）和脾集落形成单位（CFU-S）的影响，以确定氯高铁血红素在原位增强原始（第7天）BFU-E水平方面是否与体外一样有效，并评估氯高铁血红素对可移植多能干细胞（CFU-S）的作用。结果表明，氯高铁血红素在体内给药后6小时内对BFU-E骨髓水平和细胞周期均有细胞特异性增强作用。未观察到对CFU-S有此类作用。
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