亮氨酸脑啡肽对日本鹌鹑（日本鹌鹑）自然饮水和血管紧张素II诱导饮水的影响。
Effects of Leu5-enkephalin on natural and angiotensin II-induced drinking in the Japanese quail (Coturnix coturnix japonica).
作者信息
Uemura H, Okawara Y, Tsukahara T, Yanaihara N, Kobayashi H
出版信息
Gen Comp Endocrinol. 1984 Nov;56(2):240-5. doi: 10.1016/0016-6480(84)90036-4.
Natural drinking behavior was inhibited by intracranial (ic) injections of Leu5-enkephalin (LEN) (30 and 60 micrograms/100 g) for 60 min, but not by iv injections (30 and 100 micrograms/100 g) in the Japanese quail. Drinking induced by angiotensin II (AII) (30 and 50 micrograms/bird, ip) was also inhibited for 60 min by LEN (40, 60, and 100 micrograms/100 g, ic), given 5 min after the AII injections. Naloxone (3 mg/bird, ip) attenuated the inhibition of LEN (60 micrograms/100 g, ic) and when administered alone (3 mg/bird, ip) induced copious drinking. These results indicated that LEN binds with central opiate receptors to inhibit natural and AII-induced drinking and that endogenous enkephalins physiologically inhibit drinking.
在日本鹌鹑中，脑内注射亮氨酸脑啡肽（LEN）（30和60微克/100克）60分钟可抑制自然饮水行为，但静脉注射（30和100微克/100克）则无此作用。在注射血管紧张素II（AII）（30和50微克/只，腹腔注射）诱导饮水后5分钟，给予LEN（40、60和100微克/100克，脑内注射）也可抑制饮水60分钟。纳洛酮（3毫克/只，腹腔注射）可减弱LEN（60微克/100克，脑内注射）的抑制作用，单独给予纳洛酮（3毫克/只，腹腔注射）则会引起大量饮水。这些结果表明，LEN与中枢阿片受体结合以抑制自然和AII诱导的饮水，并且内源性脑啡肽在生理上抑制饮水。
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