表达显性致死母本效应的重组小鼠T单倍型的特征分析。
Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect.
作者信息
Winking H, Silver L M
出版信息
Genetics. 1984 Dec;108(4):1013-20. doi: 10.1093/genetics/108.4.1013.
Abstract
The twLub2 chromosome was generated by rare recombination between a complete t haplotype and a wild-type form of mouse chromosome 17. This recombinant chromosome expresses a dominant lethal effect in all embryos that inherit the mutant chromosome from their mothers. The phenotype of this maternal effect is indistinguishable from that expressed by the previously described Thp deletion chromosome. It appears likely that the crossing over event that gave rise to twLub2 was unequal and resulted in the alteration or deletion of a gene (which is named the T-associated maternal effect locus, Tme) that must be inherited from the mother in order for normal development to proceed through late stages of gestation. The results presented here allow a mapping of the Tme locus between the quaking and tufted loci which are 3 cM apart within the proximal region of chromosome 17.
摘要
twLub2染色体是由完整的t单倍型与野生型小鼠17号染色体之间的罕见重组产生的。这条重组染色体在所有从母亲那里继承了突变染色体的胚胎中表现出显性致死效应。这种母体效应的表型与先前描述的Thp缺失染色体所表现的表型无法区分。产生twLub2的交叉事件似乎是不等的，并导致了一个基因（命名为T相关母体效应位点，Tme）的改变或缺失，该基因必须从母亲那里遗传才能使正常发育进行到妊娠后期。此处给出的结果使得能够将Tme位点定位在染色体17近端区域内相距3厘摩的颤抖和簇状位点之间。
相似文献
1
Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect.表达显性致死母本效应的重组小鼠T单倍型的特征分析。
Genetics. 1984 Dec;108(4):1013-20. doi: 10.1093/genetics/108.4.1013.
2
Nonhomologous pairing in mice heterozygous for a t haplotype can produce recombinant chromosomes with duplications and deletions.对于携带t单倍型的杂合小鼠，非同源配对可产生具有重复和缺失的重组染色体。
Genetics. 1986 Jul;113(3):723-34. doi: 10.1093/genetics/113.3.723.
3
Paternal transmission of the mouse Thp mutation is lethal in some genetic backgrounds.在某些遗传背景下，小鼠Thp突变的父系传递是致死性的。
Dev Genet. 1997;20(1):23-8. doi: 10.1002/(SICI)1520-6408(1997)20:1<23::AID-DVG3>3.0.CO;2-B.
4
Genetic and developmental studies of a new mouse mutation that produces otocephaly.
J Craniofac Genet Dev Biol. 1985;5(2):121-45.
5
Effects of zero to four copies of chromosome 15 on mouse embryonic development.
Cytogenet Cell Genet. 1988;47(1-2):66-71. doi: 10.1159/000132508.
6
TOr1 is a novel, variant form of mouse chromosome 17 with a deletion in a partial t haplotype.
Nature. 1983 Feb 3;301(5899):422-4. doi: 10.1038/301422a0.
7
Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.在携带Igf-2和Igf2r（两个相互印记的基因）无效突变的小鼠中挽救T相关母体效应。
Development. 1993 Jul;118(3):731-6. doi: 10.1242/dev.118.3.731.
8
Recombination suppression of mouse t-haplotypes due to chromatin mismatching.由于染色质错配导致小鼠t单倍型的重组抑制
Nature. 1981 Mar 5;290(5801):68-70. doi: 10.1038/290068a0.
9
Tcp-1 gene is not responsible for the maternal lethality effect of Thp mutation in mice.
Dev Biol. 1991 Feb;143(2):374-7. doi: 10.1016/0012-1606(91)90087-j.
10
[Two doses of the paternal Tme gene do not compensate for the lethality of the Thp deletion in mice].
Genetika. 1990 Nov;26(11):2076-8.
引用本文的文献
1
Canonical and Non-canonical Genomic Imprinting in Rodents.啮齿动物中的典型和非典型基因组印记
Front Cell Dev Biol. 2021 Aug 5;9:713878. doi: 10.3389/fcell.2021.713878. eCollection 2021.
2
The haplolethality paradox of the wupA gene in Drosophila.果蝇 wupA 基因的单体致死悖论。
PLoS Genet. 2021 Mar 19;17(3):e1009108. doi: 10.1371/journal.pgen.1009108. eCollection 2021 Mar.
3
The use of unilateral PCR to identify prominent heteroduplexes formed during PCR of the mouse microsatellite locus D17Mit23.使用单向PCR鉴定小鼠微卫星基因座D17Mit23在PCR过程中形成的显著异源双链体。
Mol Biotechnol. 2006 May;33(1):37-48. doi: 10.1385/MB:33:1:37.
4
Overlapping deletions spanning the proximal two-thirds of the mouse t complex.跨越小鼠t复合体近端三分之二区域的重叠缺失。
Mamm Genome. 2003 Dec;14(12):817-29. doi: 10.1007/s00335-003-2298-4.
5
Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA.在小鼠t复合体基因组DNA的60 kb范围内聚集的三个基因的随机单等位基因表达。
Genome Res. 2001 Nov;11(11):1833-41. doi: 10.1101/gr.194301.
6
Genetic imprinting in the mouse: implications for gene regulation.小鼠中的基因印记：对基因调控的影响。
J Inherit Metab Dis. 1994;17(4):403-20. doi: 10.1007/BF00711356.
7
Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus.对包含震颤基因座致死等位基因的小鼠t区域进行饱和生殖系诱变。
Proc Natl Acad Sci U S A. 1988 Jan;85(1):180-4. doi: 10.1073/pnas.85.1.180.
8
Normal testis determination in the mouse depends on genetic interaction of a locus on chromosome 17 and the Y chromosome.小鼠正常睾丸的形成取决于17号染色体上一个基因座与Y染色体之间的基因相互作用。
Genetics. 1989 Sep;123(1):173-9. doi: 10.1093/genetics/123.1.173.
9
Molecular characterization of four intra-t mouse recombinants.四只体内重组小鼠的分子特征分析。
Immunogenetics. 1989;30(2):112-8. doi: 10.1007/BF02421539.
10
Genetic evidence for two t complex tail interaction (tct) loci in t haplotypes.t单倍型中两个t复合尾部相互作用（tct）位点的遗传证据。
Genetics. 1989 Aug;122(4):895-903. doi: 10.1093/genetics/122.4.895.
本文引用的文献
1
Molecular analysis of the genetic relationship of trans interacting factors at the T/t complex.
Nature. 1980 Nov 27;288(5789):368-70. doi: 10.1038/288368a0.
2
Evidence for two regions in the mouse t complex controlling transmission ratios.小鼠t复合体中控制传递比率的两个区域的证据。
Genet Res. 1981 Dec;38(3):315-25. doi: 10.1017/s0016672300020632.
3
Genetic organization of the mouse t complex.小鼠t复合体的基因组织
Cell. 1981 Dec;27(2 Pt 1):239-40. doi: 10.1016/0092-8674(81)90406-2.
4
Evidence for unequal crossing over within the mouse T/t complex.小鼠T/t复合体中不等交换的证据。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6077-80. doi: 10.1073/pnas.77.10.6077.
5
Reevaluation of the evidence for the generation of new lethal t haplotypes by mutation.对通过突变产生新的致死性t单倍型的证据的重新评估。
Immunogenetics. 1983;18(1):91-6. doi: 10.1007/BF00401359.
6
Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes.从小鼠中期染色体显微切割获得的t复合体的分子克隆。
Cell. 1984 Mar;36(3):783-8. doi: 10.1016/0092-8674(84)90358-1.
7
Rescue of a lethal T/t locus genotype by chimaerism with normal embryos.
Nature. 1978 Apr 6;272(5653):539. doi: 10.1038/272539a0.
8
A major testicular cell protein specified by a mouse T/t complex gene.
Cell. 1979 Jun;17(2):275-84. doi: 10.1016/0092-8674(79)90153-3.
Zotero 插件