Platia E V, Whelton P K
Johns Hopkins Med J. 1978 May;142(5):152-4.
We describe the clinical course of a patient who developed anuria following prophylactic methicillin administration. To the best of our knowledge, this is the first report of prolonged anuria following administration of this drug. The patient's nephropathy developed as a result of routine perioperative antibiotic prophylaxis for cardiac surgery and resulted in a two-week period of complete anuria. Following discontinuation of methicillin the patient was supported throughout this period by intermittent hemodialysis and eventually had an excellent recovery of renal function without concurrent use of corticosteroids. Thus methicillin may occasionally cause severe and prolonged anuric renal failure, but maximal supportive measures, including dialysis when necessary, should nonetheless be used, since the renal failure is reversible once the antibiotic is discontinued.
我们描述了一名患者在预防性使用甲氧西林后出现无尿的临床过程。据我们所知，这是该药物使用后出现长时间无尿的首例报告。该患者的肾病是心脏手术围手术期常规抗生素预防导致的，结果出现了为期两周的完全无尿。停用甲氧西林后，在此期间患者通过间歇性血液透析得到支持，最终肾功能出色恢复，未同时使用皮质类固醇。因此，甲氧西林偶尔可能导致严重且持久的无尿性肾衰竭，但仍应采取最大程度的支持措施，必要时包括透析，因为一旦停用抗生素，肾衰竭是可逆的。
