Mattrey R F, Andrè M, Campbell J, Mitten R, Multer F, Hackney D, Long D M, Higgins C B
Invest Radiol. 1984 Sep-Oct;19(5):438-46. doi: 10.1097/00004424-198409000-00017.
Perfluoroctylbromide (PFOB), a radiopaque reticuloendothelial system contrast media for computed tomography, has been shown to accumulate in macrophages. In the current study PFOB was tested in rabbits as an abscess imaging agent. Two abscesses were induced in each of 24 rabbits, one in the liver and the other in the peritoneal cavity. CT of the rabbit abdomen was performed four days later, two days after the administration of 5 gm/Kg of PFOB to 12 of these rabbits. The average enhancement of the wall of liver abscesses was by 140 Hounsfield units (HU) relative to the enhanced liver and peritoneal abscesses by 135 HU relative to the control group. This enhancement was secondary to the intense accumulation of PFOB filled macrophages in the abscess wall. In those rabbits where the liver abscess ruptured, the edges of the peritoneal collections enhanced by 147 HU. Regions of inflammation prior to liquifaction enhanced considerably. These areas could not be detected in the animals not receiving PFOB. Though the liquified center of liver abscesses could be seen in the absence of PFOB, none of the peritoneal abscesses could be detected in the animals not receiving PFOB. In contradistinction, all peritoneal abscesses enhanced considerably following PFOB allowing their prospective localization. In conclusion, PFOB accumulates in abscess walls and areas of inflammation producing marked CT enhancement of liver and peritoneal abscess collections. This enhancement allowed the differentiation of peritoneal abscess collections from adjacent bowel.
全氟辛基溴（PFOB）是一种用于计算机断层扫描的不透射线的网状内皮系统造影剂，已被证明可在巨噬细胞中蓄积。在本研究中，对家兔进行了PFOB作为脓肿成像剂的测试。给24只家兔每只诱导出两个脓肿，一个在肝脏，另一个在腹腔。四天后，即给其中12只家兔注射5克/千克PFOB两天后，对兔腹部进行CT检查。肝脓肿壁相对于强化后的肝脏平均增强140亨氏单位（HU），腹腔脓肿相对于对照组增强135 HU。这种增强是由于脓肿壁中充满PFOB的巨噬细胞大量蓄积所致。在肝脓肿破裂的家兔中，腹腔积液边缘增强147 HU。液化前的炎症区域增强明显。在未接受PFOB的动物中无法检测到这些区域。虽然在未使用PFOB的情况下可以看到肝脓肿的液化中心，但在未接受PFOB的动物中无法检测到任何腹腔脓肿。相反，PFOB注射后所有腹腔脓肿均有明显增强，从而可以对其进行前瞻性定位。总之，PFOB在脓肿壁和炎症区域蓄积，使肝脏和腹腔脓肿在CT上有明显增强。这种增强使得能够将腹腔脓肿与相邻肠管区分开来。
