Leoncini G, Maresca M
Ital J Biochem. 1984 Jul-Aug;33(4):221-9.
In this study we have reported that platelets metabolize fructose more slowly than glucose and probably by a different mechanism. While formed lactate is correlated with glucose utilized, in the presence of fructose an overproduction of lactate was demonstrated. The different behaviour of glucose and fructose was also shown by utilizing diamide at various concentrations. Low diamide concentrations increase glucose consumption, whereas higher concentrations inhibit. Fructose is gradually inhibited by increasing oxidant quantities. Data obtained suggests that diamide interferes with the transport process across platelet membrane. It is likely that glucose and fructose do not share the same transport mechanism. On the other hand only high diamide concentrations inhibit sugar metabolism by acting on the glycolytic flux at the level of some key enzymes.
在本研究中，我们报告血小板代谢果糖的速度比葡萄糖慢，且可能通过不同机制进行。虽然生成的乳酸与所利用的葡萄糖相关，但在果糖存在的情况下，显示出乳酸过量产生。通过使用不同浓度的二酰胺也表明了葡萄糖和果糖的不同行为。低浓度二酰胺会增加葡萄糖消耗，而高浓度则会抑制。随着氧化剂数量增加，果糖逐渐受到抑制。所获得的数据表明二酰胺会干扰跨血小板膜的转运过程。葡萄糖和果糖很可能不共享相同的转运机制。另一方面，只有高浓度二酰胺通过作用于某些关键酶水平的糖酵解通量来抑制糖代谢。
