Nikolaenko E M, Katkov V E, Gvozdev S V, Chestukhin V V, Volkova M I
Kosm Biol Aviakosm Med. 1984 Nov-Dec;18(6):40-4.
The time-course variation of the water content of the lungs of seven male volunteers were examined during 7-day head-down tilt (at -15 degrees). As compared to the horizontal subjects, the tilted subjects showed a significant increase in the water content from 557 +/- 19 ml to 612 +/- +/- 63 ml by the 7th hour of the tilt. Later on the parameter gradually declined and on tilt day 7 almost returned to the pretest level, i.e., 567 +/- 46 ml. This increase in the water content during the first hours of the exposure can be attributed to the hydrostatic factors: higher pulmonary artery pressure and higher cardiac output. The increase in the water content on tilt days 3-7 can be associated with changes in the permeability of lung capillaries, drainage function of the lymphatic system of the lungs, and colloidal-osmotic pressure in the perivascular space of the lungs.
对7名男性志愿者在7天头低位倾斜（-15度）期间肺含水量的时程变化进行了检测。与处于水平位的受试者相比，倾斜的受试者在倾斜第7小时时肺含水量从557±19毫升显著增加至612±63毫升。之后该参数逐渐下降，到倾斜第7天时几乎恢复到测试前水平，即567±46毫升。暴露最初几小时内肺含水量的增加可归因于流体静力因素：肺动脉压升高和心输出量增加。倾斜第3 - 7天肺含水量的增加可能与肺毛细血管通透性、肺淋巴系统引流功能以及肺血管周围间隙胶体渗透压的变化有关。
