Brunner G
Leber Magen Darm. 1984 Nov;14(6):276-81.
Recently lipophilic fluid membrane hollow fiber modules have been developed, which allow continuous extracorporal enzymatic detoxification by elimination of endogenous toxins out of the blood in vivo without loss of enzymatic activity and without immunological risks. The clearance for phenol glucuronisation is 6.8 nMol/min/mg enzyme protein/cm2 hollow fiber surface the hydroxylation rate for dodecanic acid using the cytochrome - P-450 system is 0.5 nMol/nMol P450/min/cm2 hollow fiber surface. Detoxification procedures using methyl, sulfat and glutathion transferase are still in an experimental phase. This new enzyme fluid membrane technology in conjunction with modified established techniques like aminoacid dialysis and plasma exchange will make possible the development of partial extracorporal substitution of liver function in the near future.
最近，亲脂性流体膜中空纤维模块已被开发出来，它能够在不损失酶活性且无免疫风险的情况下，通过在体内从血液中清除内源性毒素来实现连续的体外酶解毒。苯酚葡萄糖醛酸化的清除率为6.8纳摩尔/分钟/毫克酶蛋白/平方厘米中空纤维表面，使用细胞色素 - P - 450系统对十二烷酸的羟化率为0.5纳摩尔/纳摩尔P450/分钟/平方厘米中空纤维表面。使用甲基、硫酸酯和谷胱甘肽转移酶的解毒程序仍处于实验阶段。这种新的酶流体膜技术与改良的成熟技术如氨基酸透析和血浆置换相结合，将在不久的将来使部分肝功能的体外替代成为可能。
