Schölmerich J, Wietholtz H, Büchsel R, Köttgen E, Löhle E, Gerok W
Leber Magen Darm. 1984 Nov;14(6):288-95.
It has been established rather surely that patients with chronic liver disease, Crohn's disease, chronic pancreatis and celiac disease are deficient in zinc and vitamin A. A large number of clinical symptoms can be caused by these deficiencies, due to the fact that these compounds have numerous functions. Zinc deficiency in liver cirrhosis is probably caused by portosystemic shunting, whereas in Crohn's disease abnormalities of protein metabolism are suggested as etiologic factor. Vitamin A deficiency can be considered as a consequence of disturbed zinc metabolism. Some studies in appropriate patients receiving substitution therapy with zinc and/or vitamin A had positive results. However, the necessity of substitution in the diseases mentioned has not yet been conclusively demonstrated.
已经相当确定的是，患有慢性肝病、克罗恩病、慢性胰腺炎和乳糜泻的患者缺乏锌和维生素A。由于这些化合物具有多种功能，这些缺乏会导致大量临床症状。肝硬化中的锌缺乏可能是由门体分流引起的，而在克罗恩病中，蛋白质代谢异常被认为是病因。维生素A缺乏可被视为锌代谢紊乱的结果。一些针对接受锌和/或维生素A替代疗法的合适患者的研究取得了积极成果。然而，上述疾病中替代疗法的必要性尚未得到确凿证实。
