Schapiro M B, Rosman N P, Kemper T L
Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):351-6.
In this investigation using Golgi techniques, the relative effects of chronic alcohol exposure and malnutrition were studied in the developing cerebral cortex of the rat. Female Sprague-Dawley albino rats were placed on one of three dietary regimens for an eight-week conditioning period: an ethanol-containing (E) liquid diet, a liquid control (LC) diet isocaloric with the E diet, and a rat chow (CH) diet. The E and LC groups were pair-fed and all diets were continued through pregnancy and lactation. In comparison to the control groups, the E group showed a significant reduction in body and brain weight with a decrease in cerebral cortical width, density of basal, oblique, and terminal spines, and extent of oblique dendrites in layer IIIb somesthetic cortical pyramidal neurons. These findings indicate that changes in the cerebral cortex in the developing rat chronically exposed to alcohol cannot be explained by malnutrition alone.
在这项使用高尔基技术的研究中，研究了慢性酒精暴露和营养不良对发育中的大鼠大脑皮层的相对影响。将雌性斯普拉格-道利白化大鼠置于三种饮食方案之一，进行为期八周的适应期：含乙醇（E）的液体饮食、与E饮食热量相等的液体对照（LC）饮食和大鼠饲料（CH）饮食。E组和LC组采用配对喂养，所有饮食持续至妊娠和哺乳期。与对照组相比，E组的体重和脑重显著降低，躯体感觉皮层Ⅲb层锥体神经元的大脑皮层宽度、基底、斜向和终末棘密度以及斜向树突范围均减小。这些发现表明，长期暴露于酒精的发育中大鼠大脑皮层的变化不能仅用营养不良来解释。
