Cullity G
Pathology. 1984 Jul;16(3):307-11. doi: 10.3109/00313028409068542.
Upward epidermal spread by tumour cells is one of the features looked for in the diagnosis of malignant melanoma. Unusual changes--resembling invasion and destruction of the epidermis--in a nevus from a 5 yr-old boy largely contributed to an erroneous diagnosis of malignant melanoma from 2 of 4 expert dermatopathologists. A subsequent prospective 5 yr survey of benign melanocytic lesions at a pediatric hospital showed 14 of over 200 nevi with prominent upward intraepidermal nevus cell migration. "Invasion" appears to be at the extreme end of a spectrum of upward spread in childhood nevi and is probably seen only in children.
肿瘤细胞向上侵袭表皮是恶性黑色素瘤诊断中需寻找的特征之一。一名5岁男孩的痣出现了类似表皮侵袭和破坏的异常变化，这在很大程度上导致4名专家皮肤病理学家中有2人错误地诊断为恶性黑色素瘤。随后在一家儿科医院对良性黑素细胞病变进行了为期5年的前瞻性调查，结果显示，在200多个痣中，有14个出现了明显的表皮内痣细胞向上迁移。“侵袭”似乎是儿童痣向上扩散范围的极端情况，可能仅在儿童中出现。
