Goldenberg R I, Poretz D M, Eron L J, Rising J B, Sparks S B
Pediatr Infect Dis. 1984 Nov-Dec;3(6):514-7. doi: 10.1097/00006454-198411000-00006.
Eighty-nine pediatric patients (median age, 12.0; range, 1.5 to 18 years) were treated with antibiotics given intravenously by self- or parent administration for a variety of infections, under close physician supervision. Patients with infections involving bone and joint (53), respiratory tract (16), soft tissue (9), abdominal cavity (4), genitourinary tract (4) and bloodstream (3) were treated for a mean period of 19.0 days. Staphylococcus aureus, Pseudomonas aeruginosa and Haemophilus influenzae were the most frequent pathogens. Favorable clinical outcomes occurred in 85 patients (96%). Adverse clinical and laboratory events occurred at a frequency commensurate with that of hospitalized patients. A total of 1700 patient days were managed in this outpatient setting at significant cost savings, and the method allowed early return to school for 83 patients (93%). Intravenous antibiotic therapy in ambulatory patients can provide a successful, safe, cost-effective alternative to inpatient care under conditions of diligent patient screening and physician-centered follow-up.
89名儿科患者（中位年龄12.0岁；范围1.5至18岁）在医生密切监督下，通过自我或家长静脉注射抗生素治疗各种感染。涉及骨与关节（53例）、呼吸道（16例）、软组织（9例）、腹腔（4例）、泌尿生殖道（4例）和血流（3例）感染的患者平均治疗19.0天。金黄色葡萄球菌、铜绿假单胞菌和流感嗜血杆菌是最常见的病原体。85例患者（96%）临床结局良好。不良临床和实验室事件的发生频率与住院患者相当。在这种门诊环境下共管理了1700个患者日，节省了大量成本，该方法使83例患者（93%）能够提前返校。在严格的患者筛查和以医生为中心的随访条件下，门诊患者的静脉抗生素治疗可以为住院治疗提供一种成功、安全且具有成本效益的替代方案。
